Comparison

Anti-PPARGC1A Antibody European Partner

Item no. BOS-A00236
Manufacturer Boster
Amount 0.1 mg
Format Liquid
Applications WB, IF, ELISA, IHC-P
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Alias LEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1(alpha), LEM6, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Ligand effect modulator 6, PGC-1-alpha
Available
Manufacturer - Category
Primary Antibodies
Storage Conditions
PPARGC1A antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight
91027 MW
Clonality
Polyclonal
Application Details
PPARGC1A antibody can be used for detection of PPARGC1A by Western blot at 1 - 2 ?g/ml. Antibody can also be used for Immunohistochemistry starting at 5 ?g/mL. For immunofluorescence start at 20 ?g/mL.
Antibody validated: Western Blot in human and mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Manufacturer - Gene Name
PPARGC1A
Gene Full Name
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Background
The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), also known as LEM-6, is a transcriptional coactivator that regulates the genes involved in energy metabolism (1). PPARGC1A interacts with PPARgamma, which permits the interaction of PPARGC1A with multiple transcription factors. PPARGC1A can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination (2). PPARGC1A may be also involved in the development of obesity (3).
Immunogen
PPARGC1A antibody was raised against a 19 amino acid peptide near the carboxy terminus of human PPARGC1A. The immunogen is located within the last 50 amino acids of PPARGC1A.
Contents
PPARGC1A antibody is supplied in PBS containing 0.02% sodium azide.
Purification
PPARGC1A antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Manufacturer - Research Category
Obesity
Protein Name
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Protein Function
Transcriptional coactivator for steroid receptors and
nuclear receptors. Greatly increases the transcriptional activity
of PPARG and thyroid hormone receptor on the uncoupling protein
promoter. Can regulate key mitochondrial genes that contribute to
the program of adaptive thermogenesis. Plays an essential role in
metabolic reprogramming in response to dietary availability
through coordination of the expression of a wide array of genes
involved in glucose and fatty acid metabolism. Induces the
expression of PERM1 in the skeletal muscle in an ESRRA-dependent
manner. Also involved in the integration of the circadian rhythms
and energy metabolism. Required for oscillatory expression of
clock genes, such as ARNTL/BMAL1 and NR1D1, through the
coactivation of RORA and RORC, and metabolic genes, such as PDK4
and PEPCK.
Subcellular Localization
Isoform 1: Nucleus. Nucleus, PML body.
Short Description
Boster Bio Anti-PPARGC1A Antibody (Catalog # A00236). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Description
Boster Bio Anti-PPARGC1A Antibody (Catalog # A00236). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity
Heart, skeletal muscle, liver and kidney.
Expressed at lower levels in brain and pancreas and at very low
levels in the intestine and white adipose tissue. In skeletal
muscle, levels were lower in obese than in lean subjects and
fasting induced a 2-fold increase in levels in the skeletal muscle
in obese subjects.
Predicted Reactivity
Pig, Bovine

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 0.1 mg
Available: In stock
available

Delivery expected until 7/31/2025 

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