Anti-Hamartin TSC1 Antibody

Primary Antibodies

129767 MW

WB: 1:500-1:1000
IHC: 1:50-1:100
ICC/IF: 1:50-1:100

Hamartin

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

In complex with TSC2, inhibits the nutrient-mediated or
growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by
negatively regulating mTORC1 signaling (PubMed:12271141,
PubMed:28215400). Seems not to be required for TSC2 GAP activity
towards RHEB (PubMed:15340059). Implicated as a tumor suppressor.
Involved in microtubule-mediated protein transport, but this seems
to be due to unregulated mTOR signaling (By similarity). Acts as a
co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of
protein clients such as kinases, TSC2 and glucocorticoid receptor
NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and
inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with
the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby
providing a reciprocal regulatory mechanism for chaperoning of
client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and
stabilizes TSC2 by preventing the interaction between TSC2 and
ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155).

Boster Bio Anti-Hamartin TSC1 Antibody catalog # A00365-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.