Anti-Lamin A/C (S17) LMNA Antibody

Primary Antibodies

74139 MW

WB: 1:500-1:1000
IHC: 1:50-1:200

Prelamin-A/C

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Lamins are components of the nuclear lamina, a fibrous
layer on the nucleoplasmic side of the inner nuclear membrane,
which is thought to provide a framework for the nuclear envelope
and may also interact with chromatin. Lamin A and C are present in
equal amounts in the lamina of mammals. Plays an important role in
nuclear assembly, chromatin organization, nuclear membrane and
telomere dynamics. Required for normal development of peripheral
nervous system and skeletal muscle and for muscle satellite cell
proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726,
PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis
and bone formation (PubMed:12075506, PubMed:15317753,
PubMed:18611980). Also prevents fat infiltration of muscle and
bone marrow, helping to maintain the volume and strength of
skeletal muscle and bone (PubMed:10587585). Required for cardiac
homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980,
PubMed:23666920).

Boster Bio Anti-Lamin A/C (S17) LMNA Antibody catalog # A00438S17. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.