Anti-BCRP/ABCG2 Antibody Picoband®

Primary Antibodies

22875 MW

ABCG2

ABCG2 (Atp-binding cassette, subfamily g, member 2) also known as ABCP, BCRP or MRX, is a protein that in humans is encoded by the ABCG2 gene. It is mapped on 4q22.1. The ABCG2 gene encodes a membrane transporter belonging to the ATP-binding cassette (ABC) superfamily of membrane transporters, which are involved in the trafficking of biologic molecules across cell membranes. The ABCG2 protein is also a high capacity transporter for uric acid excretion in the kidney, liver, and gut. In vitro assays of isolated membrane preparations revealed a high-capacity, vanadate-sensitive ATPase activity associated with ABCG2 expression that was stimulated by compounds known to be transported by this protein. ABCG2 is likely functioning as a homodimer or homooligomer in this expression system since it is unlikely that putative Sf9 transport partners would be overexpressed at similarly high levels. Abcg2 transports pheophorbide-a, which occurs in various plant-derived foods and food supplements and is highly efficient in limiting its uptake from ingested food. ABCG2 is a major factor in the concentrative transfer of drugs, carcinogens, and dietary toxins to the milk of mice, cows, and humans.

Each vial contains 50% glycerol,  0.9% NaCl,  0.2% Na2HPO4,  0.02% NaN3.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Immunoglobulins, Immunology

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Detected in lung, spleen, uterus, vagina and epididymis. .