« Back
Home /
Anti-IL-21 Antibody

Anti-IL-21 Antibody

Item no.	BOS-A00459
Manufacturer	Boster
Amount	0.1 mg
Category	Cell Biology Cell Culture Cytokines Immunohistochemistry Western Blot ELISA Immunostaining
Format	Liquid
Applications	WB, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Alias	Za11,IL-21,Interleukin-21,Za11
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	IL-21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	17923 MW
Clonality	Polyclonal
Application Details	WB: 0.5-2 μg/mL; IHC-P: 0.5-2 μg/mL. Antibody validated: Western Blot and Immunohistochemistry in human, mouse and rat samples. All other applications and species not yet tested.
Gene Name	IL21
Gene Full Name	Interleukin 21
Manufacturer - Specificity	At least two isoforms of IL-21 are known to exist; this antibody will detect both isoforms. IL-21 antibody is predicted to not cross-react with other members of the interleukin protein family.
Background	A novel cytokine was recently identified in human and mouse and designated IL-21, which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Immunogen	Anti-IL-21 antibody was raised against a peptide corresponding to 15 amino acids near the center of human IL-21 precursor. The immunogen is located within the last 50 amino acids of IL-21.
Contents	IL-21 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	IL-21 Antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/ml
Manufacturer - Research Category	Chemokines, Cytokines, Cancer
Protein Name	Interleukin 21
Protein Function	Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG (1) and IgG (3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Subcellular Localization	Secreted
Description	Boster Bio Anti-IL-21 Antibody (Catalog # A00459). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
Short Description	Boster Bio Anti-IL-21 Antibody (Catalog # A00459). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat.
Predicted Reactivity	Bovine, Pig
Manufacturer - Cross Reactivity	At least two isoforms of IL-21 are known to exist; this antibody will detect both isoforms. IL-21 antibody is predicted to not cross-react with other members of the interleukin protein family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A00459-datasheet.pdf

BOS-A00459-safety-datasheet.pdf