Anti-TMPRSS2 Antibody

Primary Antibodies

53859 MW

WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200

Transmembrane protease serine 2

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Serine protease that proteolytically cleaves and
activates the viral spike glycoproteins which facilitate virus-
cell membrane fusions; spike proteins are synthesized and
maintained in precursor intermediate folding states and
proteolysis permits the refolding and energy release required to
create stable virus-cell linkages and membrane coalescence.
Facilitates human SARS coronavirus (SARS-CoV) infection via two
independent mechanisms, proteolytic cleavage of ACE2, which might
promote viral uptake, and cleavage of coronavirus spike
glycoprotein which activates the glycoprotein for cathepsin L-
independent host cell entry. Proteolytically cleaves and activates
the spike glycoproteins of human coronavirus 229E (HCoV-229E) and
human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0
of Sendai virus (SeV), human metapneumovirus (HMPV), human
parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for
spread and pathogenesis of influenza A virus (strains H1N1, H3N2
and H7N9); involved in proteolytic cleavage and activation of
hemagglutinin (HA) protein which is essential for viral
infectivity.

Boster Bio Anti-TMPRSS2 Antibody catalog # A00666. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.