Anti-Bid Antibody

Bid antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Polyclonal

BID

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bid, a pro-apoptotic Bcl-2 family member, is cleaved by caspase-8 in response to apoptotic signals, exposing the Bcl-2 homology 3 (BH3) domain which is normally buried in the full-length protein. The cleaved complex is myris-toylated and translocated to the mitochondrial membrane where it may induce mitochondrial Bax and Bak to oligomerize.

Bid Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

BH3 interacting domain death agonist

Cytoplasm

Isoform 2 and isoform 3 are expressed in
spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is
expressed in spleen, pancreas and placenta (at protein level).
Isoform 3 is expressed in lung, pancreas and spleen (at protein
level). Isoform 4 is expressed in lung and pancreas (at protein
level).