Anti-Phospho-Flk-1 (Y951) KDR Antibody

Primary Antibodies

151527 MW

WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000

Vascular endothelial growth factor receptor 2

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

1 mg/ml

Tyrosine-protein kinase that acts as a cell-surface
receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in
the regulation of angiogenesis, vascular development, vascular
permeability, and embryonic hematopoiesis. Promotes proliferation,
survival, migration and differentiation of endothelial cells.
Promotes reorganization of the actin cytoskeleton. Isoforms
lacking a transmembrane domain, such as isoform 2 and isoform 3,
may function as decoy receptors for VEGFA, VEGFC and/or VEGFD.
Isoform 2 plays an important role as negative regulator of
VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount
of free VEGFA and/or VEGFC and preventing their binding to FLT4.
Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding
of vascular growth factors to isoform 1 leads to the activation of
several signaling cascades. Activation of PLCG1 leads to the
production of the cellular signaling molecules diacylglycerol and
inositol 1, 4, 5-trisphosphate and the activation of protein kinase
C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP
kinase signaling pathway, as well as of the AKT1 signaling
pathway. Mediates phosphorylation of PIK3R1, the regulatory
subunit of phosphatidylinositol 3-kinase, reorganization of the
actin cytoskeleton and activation of PTK2/FAK1. Required for
VEGFA-mediated induction of NOS2 and NOS3, leading to the
production of the signaling molecule nitric oxide (NO) by
endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation
of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.

Boster Bio Anti-Phospho-Flk-1 (Y951) KDR Antibody catalog # A00901Y951-1. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse.

Boster Bio Anti-Phospho-Flk-1 (Y951) KDR Antibody catalog # A00901Y951-1. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Mouse.