Anti-HIPK2 Antibody

Primary Antibodies

130966 MW

WB: 1:500-1:1000

Homeodomain-interacting protein kinase 2

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Serine/threonine-protein kinase involved in
transcription regulation, p53/TP53-mediated cellular apoptosis and
regulation of the cell cycle. Acts as a corepressor of several
transcription factors, including SMAD1 and POU4F1/Brn3a and
probably NK homeodomain transcription factors. Phosphorylates
PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300,
CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes
apoptosis through the activation of p53/TP53 both at the
transcription level and at the protein level (by phosphorylation
and indirect acetylation). The phosphorylation of p53/TP53 may be
mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the
response to hypoxia by acting as a transcriptional co-suppressor
of HIF1A. Mediates transcriptional activation of TP73. In response
to TGFB, cooperates with DAXX to activate JNK. Negative regulator
through phosphorylation and subsequent proteasomal degradation of
CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin
signaling pathway acts as an intermediate kinase between
MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB.
Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-
protein ligase activity. Activates CREB1 and ATF1 transcription
factors by phosphorylation in response to genotoxic stress. In
response to DNA damage, stabilizes PML by phosphorylation. PML,
HIPK2 and FBXO3 may act synergically to activate p53/TP53-
dependent transactivation. Promotes angiogenesis, and is involved
in erythroid differentiation, especially during fetal liver
erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates
EP300 transcription regulation activity. Triggers ZBTB4 protein
degradation in response to DNA damage. Modulates HMGA1 DNA-binding
affinity. In response to high glucose, triggers phosphorylation-
mediated subnuclear localization shifting of PDX1. Involved in the
regulation of eye size, lens formation and retinal lamination
during late embryogenesis.

Boster Bio Anti-HIPK2 Antibody catalog # A01371. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.