Anti-Bone marrow stromal antigen 2 BST2 Antibody

Primary Antibodies

19769 MW

WB: 1:500
IHC: 1:50-1:200
FC: 1:50-1:100

Bone marrow stromal antigen 2

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

IFN-induced antiviral host restriction factor which
efficiently blocks the release of diverse mammalian enveloped
viruses by directly tethering nascent virions to the membranes of
infected cells. Acts as a direct physical tether, holding virions
to the cell membrane and linking virions to each other. The
tethered virions can be internalized by endocytosis and
subsequently degraded or they can remain on the cell surface. In
either case, their spread as cell-free virions is restricted. Its
target viruses belong to diverse families, including retroviridae:
human immunodeficiency virus type 1 (HIV-1), human
immunodeficiency virus type 2 (HIV-2), simian immunodeficiency
viruses (SIVs), equine infectious anemia virus (EIAV), feline
immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-
Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1
(HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus
(MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola
virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus
(LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-
associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis
virus (VSV), orthomyxoviridae: influenza A virus, and
paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic
activity of MMP14 causing decreased activation of MMP15 which
results in inhibition of cell growth and migration. Can stimulate
signaling by LILRA4/ILT7 and consequently provide negative
feedback to the production of IFN by plasmacytoid dendritic cells
in response to viral infection (PubMed:19564354, PubMed:26172439).
Plays a role in the organization of the subapical actin
cytoskeleton in polarized epithelial cells. Isoform 1 and isoform
2 are both effective viral restriction factors but have differing
antiviral and signaling activities (PubMed:23028328,
PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated
degradation and restricts HIV-1 viral budding in the presence of
Vpu (PubMed:23028328, PubMed:26172439). Isoform 1 acts as an
activator of NF-kappa-B and this activity is inhibited by isoform
2 (PubMed:23028328).

Boster Bio Anti-Bone marrow stromal antigen 2 BST2 Antibody catalog # A00934-2. Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Human.