Anti-Antigen peptide transporter 1 TAP1 Antibody

Primary Antibodies

87218 MW

WB 1:500-2000
ELISA 1:5000-20000

Antigen peptide transporter 1

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.

1 mg/ml

Involved in the transport of antigens from the cytoplasm
to the endoplasmic reticulum for association with MHC class I
molecules. Also acts as a molecular scaffold for the final stage
of MHC class I folding, namely the binding of peptide. Nascent MHC
class I molecules associate with TAP via tapasin. Inhibited by the
covalent attachment of herpes simplex virus ICP47 protein, which
blocks the peptide-binding site of TAP. Inhibited by human
cytomegalovirus US6 glycoprotein, which binds to the lumenal side
of the TAP complex and inhibits peptide translocation by
specifically blocking ATP-binding to TAP1 and prevents the
conformational rearrangement of TAP induced by peptide binding.
Inhibited by human adenovirus E3-19K glycoprotein, which binds the
TAP complex and acts as a tapasin inhibitor, preventing MHC class
I/TAP association. Expression of TAP1 is down-regulated by human
Epstein-Barr virus vIL-10 protein, thereby affecting the transport
of peptides into the endoplasmic reticulum and subsequent peptide
loading by MHC class I molecules.

Boster Bio Anti-Antigen peptide transporter 1 TAP1 Antibody catalog # A01123-1. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Antigen peptide transporter 1, APT1, ATP-binding cassette sub-family B member 2, Peptide supply factor 1, Peptide transporter PSF1, PSF-1, Peptide transporter TAP1, Peptide transporter involved in antigen processing 1, Really interesting new gene 4 protein, TAP1, ABCB2, PSF1, RING4, Y3