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Anti-IL-11 Antibody

Anti-IL-11 Antibody

Item no.	BOS-A01160-2
Manufacturer	Boster
Amount	0.1 mg
Quantity options	0.1 mg 100 ul
Category	Western Blot ELISA Immunofluorescence Immunocytochemistry Immunostaining Immunochemistry
Format	Liquid
Applications	WB, IF, ICC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Alias	Interleukin-11,Adipogenesis inhibitory factor,AGIF
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	IL-11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Molecular Weight	21429 MW
Clonality	Polyclonal
Application Details	IL-11 antibody can be used for the detection of IL-11 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry at 10 μg/ml. Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Gene Name	IL-11
Gene Full Name	Interleukin 11
Manufacturer - Specificity	IL-11 antibody is human specific. At least two isoforms of IL-11 are known to exist; this antibody will only detect the longest isoform of IL-11.
Background	Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4).
Immunogen	IL-11 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-11. The immunogen is located within amino acids 40 - 90 of IL-11.
Contents	IL-11 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	IL-11 Antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/mL
Manufacturer - Research Category	Stem Cells, Immunology
Protein Name	Interleukin 11
Protein Function	Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
Subcellular Localization	Secreted
Description	Boster Bio Anti-IL-11 Antibody (Catalog # A01160-2). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.
Predicted Reactivity	Rat, Mouse
Manufacturer - Cross Reactivity	IL-11 antibody is human specific. At least two isoforms of IL-11 are known to exist; this antibody will only detect the longest isoform of IL-11.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A01160-2-datasheet.pdf

BOS-A01160-2-safety-datasheet.pdf