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Anti-Bim/Bcl2l11 Antibody Picoband®

Anti-Bim/Bcl2l11 Antibody Picoband®

Item no.	BOS-A01552-5-Dylight594
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Oncology By Cell Type Carcinoma Hematology Leukemia Lymphoma Cell Biology Cell Status Flow Cytometry Western Blot ELISA Autophagy Immunostaining
Format	Lyophilized
Applications	WB, FC, ELISA
Specific against	Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	DyLight 594
Citations	1. Bouillet, P., Metcalf, D., Huang, D. C. S., Tarlinton, D. M., Kay, T. W. H., Kontgen, F., Adams, J. M., Strasser, A. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738, 1999. 2. Bouillet, P., Purton, J. F., Godfrey, D. I., Zhang, L.-C., Coultas, L., Puthalakath, H., Pellegrini, M., Cory, S., Adams, J. M., Strasser, A. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415: 922-926, 2002. Note: Erratum: Nature 618: 108 only, 2002. 3. Bouillet, P., Zhang, L. C., Huang, D. C. S., Webb, G. C., Bottema, C. D. K., Shore, P., Eyre, H. J., Sutherland, G. R., Adams, J. M. Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim. Mammalian Genome 12: 163-168, 2001.
Alias	70 kDa ribosomal protein S6 kinase 1 antibody,KS6B1_HUMAN antibody,p70 alpha antibody,P70 beta 1 antibody,p70 ribosomal S6 kinase alpha antibody,p70 ribosomal S6 kinase beta 1 antibody,p70 S6 kinase alpha antibody,P70 S6 Kinase antibody,p70 S6 kinase alpha 1 antibody,p70 S6 kinase alpha 2 antibody,p70 S6K antibody,p70 S6K-alpha antibody,p70 S6KA antibody,p70(S6K) alpha antibody,p70(S6K)-alpha antibody,p70-alpha antibody,p70-S6K 1 antibody,p70-S6K antibody,P70S6K antibody,P70S6K1 antibody,p70S6Kb antibody,PS6K antibody,Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody,Ribosomal protein S6 kinase beta 1 antibody,Ribosomal protein S6 kinase beta-1 antibody,Ribosomal protein S6 kinase I antibody,RPS6KB1 antibody,S6K antibody,S6K-beta-1 antibody,S6K1 antibody,Serine/threonine kinase 14 alpha antibody,Serine/threonine-protein kinase 14A antibody,STK14A antibody
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
Observed Molecular weight	22 kDa
Calculated Molecular weight	52588 MW
Clonality	Polyclonal
Application Details	Western blot, 0.25-0.5 μg/ml, Mouse Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Mouse ELISA, 0.1-0.5 μg/ml
Gene Name	Bcl2l11
Gene Full Name	Serine/threonine-protein kinase AtPK1/AtPK6
Background	Bcl-2-like protein 11, commonly called BIM (Bcl-2?Interacting?Mediator of cell death), is a?protein?that in humans is encoded by the?BCL2L11?gene. BCL2 is a prototypic mammalian regulator of cell death. Certain members of the BCL2 family inhibit apoptosis, while other members facilitate this physiologic process of cell death. By screening a cDNA expression library using recombinant BCL2 as bait, O'Connor et al. isolated a small novel protein, which they referred to as BIM, with a 9-amino acid BH3 motif shared by most BCL2 homologs. BIM provokes apoptosis, and the BH3 region is required for BCL2 binding and for most of its cytotoxicity.
Immunogen	E.coli-derived mouse Bim/Bcl2l11 recombinant protein (Position: Q18-R186). Mouse Bcl2l11 shares 86.7% and 98.8% amino acid (aa) sequence identity with human and rat Bcl2l11, respectively.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Signal Transduction, Signaling Pathway, Small G Proteins
Protein Name	Serine/threonine-protein kinase AtPK1/AtPK6
Protein Function	Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.
Subcellular Localization	Cytoplasm. Nucleus.
Description	Boster Bio Anti-Bim/Bcl2l11 Antibody Picoband® catalog # A01182-4. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Expressed in all tissues.
Manufacturer - Alias	70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Manufacturer - Cross Reactivity	No cross reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A01552-5-Dylight594-datasheet.pdf

BOS-A01552-5-Dylight594-safety-datasheet.pdf