Anti-LAMP2a Antibody

Primary Antibodies

44961 MW

WB: 1:1, 000-1:5, 000
IHC: 1:50-1:200

Lysosome-associated membrane glycoprotein 2

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Plays an important role in chaperone-mediated autophagy,
a process that mediates lysosomal degradation of proteins in
response to various stresses and as part of the normal turnover of
proteins with a long biological half-live (PubMed:8662539,
PubMed:11082038, PubMed:18644871, PubMed:24880125,
PubMed:27628032). Functions by binding target proteins, such as
GAPDH and MLLT11, and targeting them for lysosomal degradation
(PubMed:8662539, PubMed:11082038, PubMed:18644871,
PubMed:24880125). Plays a role in lysosomal protein degradation in
response to starvation (By similarity). Required for the fusion of
autophagosomes with lysosomes during autophagy (PubMed:27628032).
Cells that lack LAMP2 express normal levels of VAMP8, but fail to
accumulate STX17 on autophagosomes, which is the most likely
explanation for the lack of fusion between autophagosomes and
lysosomes (PubMed:27628032). Required for normal degradation of
the contents of autophagosomes (PubMed:27628032). Required for
efficient MHCII-mediated presentation of exogenous antigens via
its function in lysosomal protein degradation; antigenic peptides
generated by proteases in the endosomal/lysosomal compartment are
captured by nascent MHCII subunits (PubMed:20518820). Is not
required for efficient MHCII-mediated presentation of endogenous
antigens (PubMed:20518820).

Boster Bio Anti-LAMP2a Antibody catalog # A01573-2. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.