Anti-MEK-4/ MAP2K4 (phospho-S80) Antibody

Primary Antibodies

44288 MW

WB: 1:500-1:1000
IHC: 1:50-1:200

Dual specificity mitogen-activated protein kinase kinase 4

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Dual specificity protein kinase which acts as an
essential component of the MAP kinase signal transduction pathway.
Essential component of the stress-activated protein kinase/c-Jun
N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,
is the one of the only known kinase to directly activate the
stress-activated protein kinase/c-Jun N-terminal kinases
MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and
MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they
differ in their preference for the phosphorylation site in the
Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of
the Tyr residue and MAP2K7/MKK7 for the Thr residue. The
phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the
prerequisite for JNK activation at least in response to
proinflammatory cytokines, while other stimuli activate both
MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate
JNKs. MAP2K4 is required for maintaining peripheral lymphoid
homeostasis. The MKK/JNK signaling pathway is also involved in
mitochondrial death signaling pathway, including the release
cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7
exclusively activates JNKs, MAP2K4/MKK4 additionally activates the
p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

Boster Bio Anti-MEK-4/ MAP2K4 (phospho-S80) Antibody catalog # A01725S80. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4, MAPKK 4, 2.7.12.2, JNK-activating kinase 1, MAPK/ERK kinase 4, MEK 4, SAPK/ERK kinase 1, SEK1, Stress-activated protein kinase kinase 1, SAPK kinase 1, SAPKK-1, SAPKK1, c-Jun N-terminal kinase kinase 1, JNKK, MAP2K4, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1