Anti-SREBF2 Antibody

Primary Antibodies

123688 MW

SREBF2 antibody can be used for detection of SREBF2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL. For Immunoflorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Sterol regulatory element binding transcription factor 2

The sterol regulatory element binding transcription factor 2 (SREBF2) is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis (1, 2). The related protein SREBF1 also binds SRE1 and activates transcription in an additive fashion to SREBF2 (2). SREBF2 has been more closely associated with cholesterol synthesis and accumulation, while the SREBF1 proteins are important in the regulation of genes involved in lipid metabolism (3).

SREBF2 antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

Sterol regulatory element binding transcription factor 2

Endoplasmic reticulum membrane; Multi-pass
membrane protein. Golgi apparatus membrane; Multi-pass membrane
protein. Cytoplasmic vesicle, COPII-coated vesicle membrane;
Multi-pass membrane protein. Moves from the endoplasmic
reticulum to the Golgi in the absence of sterols.

Ubiquitously expressed in adult and fetal
tissues.

SREBF2 antibody is human and mouse reactive. At least three isoforms of SREBF2 are known to exist. SREBF2 antibody is predicted not to cross-react with SREBF1.