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Anti-CIDE-A Antibody

Anti-CIDE-A Antibody

Item no.	BOS-A02671-1
Manufacturer	Boster
Amount	0.1 mg
Quantity options	0.1 mg 0.1 mg
Category	Metabolism Diabetes Glucose Homeostasis Obesity Immunohistochemistry Western Blot ELISA Immunofluorescence Immunostaining
Format	Liquid
Applications	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Alias	CIDE-A,Cell death activator CIDE-A,Cell death-inducing DFFA-like effector A
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	CIDE-A antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	24687 MW
Clonality	Polyclonal
Application Details	CIDE-A antibody can be used for detection of CIDE-A by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Gene Name	CIDEA
Gene Full Name	Cell death-inducing DFFA-like effector a
Manufacturer - Specificity	It has no cross activity to CIDE-B.
Background	Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-A is expressed in many tissues.
Immunogen	CIDE-A antibody was raised against an 18 amino acid peptide near the carboxy terminus of mouse CIDE-A. The immunogen is located within the last 50 amino acids of CIDE-A.
Contents	CIDE-A Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	CIDE-A Antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/mL
Manufacturer - Research Category	Apoptosis
Protein Name	Cell death-inducing DFFA-like effector a
Protein Function	Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
Subcellular Localization	Lipid droplet
Description	Boster Bio Anti-CIDE-A Antibody (Catalog # A02671-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Tissue Specificity	Expressed in omental and subcutaneous adipose tissue (at protein level).
Manufacturer - Cross Reactivity	It has no cross activity to CIDE-B.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-A02671-1-datasheet.pdf

BOS-A02671-1-safety-datasheet.pdf