Anti-STRA6 Antibody

Primary Antibodies

73503 MW

WB: 1:500-1:2000

Receptor for retinol uptake STRA6

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Functions as retinol transporter. Accepts all-trans
retinol from the extracellular retinol-binding protein RBP4,
facilitates retinol transport across the cell membrane, and then
transfers retinol to the cytoplasmic retinol-binding protein RBP1
(PubMed:9452451, PubMed:18316031, PubMed:22665496). Retinol uptake
is enhanced by LRAT, an enzyme that converts retinol to all-trans
retinyl esters, the storage forms of vitamin A (PubMed:18316031,
PubMed:22665496). Contributes to the activation of a signaling
cascade that depends on retinol transport and LRAT-dependent
generation of retinol metabolites that then trigger activation of
JAK2 and its target STAT5, and ultimately increase the expression
of SOCS3 and inhibit cellular responses to insulin
(PubMed:21368206, PubMed:22665496). Important for the homeostasis
of vitamin A and its derivatives, such as retinoic acid
(PubMed:18316031). STRA6-mediated transport is particularly
important in the eye, and under conditions of dietary vitamin A
deficiency (Probable). Does not transport retinoic acid
(PubMed:18316031).

Boster Bio Anti-STRA6 Antibody catalog # A03792. Tested in WB applications. This antibody reacts with Human.