« Back
Home /
Anti-ERAB HSD17B10 Antibody

Anti-ERAB HSD17B10 Antibody

Item no.	BOS-A03844
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Metabolism Diabetes Neural Mitochondrial Function Immunohistochemistry Western Blot Immunofluorescence Immunocytochemistry Immunochemistry
Format	Liquid
Applications	WB, IF, IHC, ICC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Alias	3-hydroxyacyl-CoA dehydrogenase type-2,1.1.1.35
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	26923 MW
Clonality	Polyclonal
Application Details	WB: 1:500-1:2000 IHC: 1:50-1:100 ICC/IF: 1:50-1:100
Gene Name	HSD17B10
Gene Full Name	3-hydroxyacyl-CoA dehydrogenase type-2
Immunogen	Recombinant fusion protein of human ERAB/ERAB/HSD17B10(NP_004484.1).
Contents	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Concentration	1 mg/ml
Protein Name	3-hydroxyacyl-CoA dehydrogenase type-2
Protein Function	Mitochondrial dehydrogenase that catalyzes the beta- oxidation at position 17 of androgens and estrogens and has 3- alpha-hydroxysteroid dehydrogenase activity with androsterone (PubMed:9553139, PubMed:23042678, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Catalyzes the third step in the beta-oxidation of fatty acids (PubMed:9553139, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (PubMed:12917011). Also exhibits 20-beta- OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426).
Subcellular Localization	Mitochondrion
Description	Boster Bio Anti-ERAB HSD17B10 Antibody catalog # A03844. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A03844-datasheet.pdf

BOS-A03844-safety-datasheet.pdf