Anti-PTPRS Antibody

Primary Antibodies

217041 MW

WB 1:500-2000
ELISA 1:5000-20000

Receptor-type tyrosine-protein phosphatase S

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.

1 mg/ml

Cell surface receptor that binds to glycosaminoglycans,
including chondroitin sulfate proteoglycans and heparan sulfate
proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and
heparan sulfate proteoglycans has opposite effects on PTPRS
oligomerization and regulation of neurite outgrowth. Contributes
to the inhibition of neurite and axonal outgrowth by chondroitin
sulfate proteoglycans, also after nerve transection. Plays a role
in stimulating neurite outgrowth in response to the heparan
sulfate proteoglycan GPC2. Required for normal brain development,
especially for normal development of the pituitary gland and the
olfactory bulb. Functions as tyrosine phosphatase
(PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and
NTRK3 (By similarity). Plays a role in down-regulation of
signaling cascades that lead to the activation of Akt and MAP
kinases (By similarity). Down-regulates TLR9-mediated activation
of NF-kappa-B, as well as production of TNF, interferon alpha and
interferon beta (PubMed:26231120).

Boster Bio Anti-PTPRS Antibody catalog # A04861. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Boster Bio Anti-PTPRS Antibody catalog # A04861. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.