Anti-GTF2H1 Antibody

Primary Antibodies

62032 MW

WB: 1:500-1:1000
ICC/IF: 1:50-1:200

General transcription factor IIH subunit 1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Component of the general transcription and DNA repair
factor IIH (TFIIH) core complex, which is involved in general and
transcription-coupled nucleotide excision repair (NER) of damaged
DNA and, when complexed to CAK, in RNA transcription by RNA
polymerase II. In NER, TFIIH acts by opening DNA around the lesion
to allow the excision of the damaged oligonucleotide and its
replacement by a new DNA fragment. In transcription, TFIIH has an
essential role in transcription initiation. When the pre-
initiation complex (PIC) has been established, TFIIH is required
for promoter opening and promoter escape. Phosphorylation of the
C-terminal tail (CTD) of the largest subunit of RNA polymerase II
by the kinase module CAK controls the initiation of transcription.

Boster Bio Anti-GTF2H1 Antibody catalog # A05408. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.