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Anti-MAP3K9 Antibody (N-term)

Anti-MAP3K9 Antibody (N-term)

Item no.	BOS-A07599-1-400ul
Manufacturer	Boster
Amount	400 ul
Quantity options	400 ul 80 ul
Category	Oncology Neuroscience Targets for Rodent Neurosciences By Cell Type Carcinoma Immunohistochemistry Western Blot
Applications	WB, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Alias	Mitogen-activated protein kinase kinase kinase 9,Mixed lineage kinase 1,MAP3K9,MLK1,PRKE1
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight	121895 Da
Clonality	Polyclonal
Application Details	WB: 1:1000 IHC-P: 1:50-1:100
Gene Name	MAP3K9
Background	Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Immunogen	This MAP3K9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-189 amino acids from the N-terminal region of human MAP3K9.
Contents	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Manufacturer - Research Category	Cell Biology, Signal Transduction
Protein Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Description	Boster Bio Anti-MAP3K9 Antibody (N-term) (Catalog # A07599-1). Tested in WB, IHC-P application(s). This antibody reacts with Human.
Tissue Specificity	Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
Predicted Reactivity	Mouse

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BOS-A07599-1-400ul-datasheet.pdf

BOS-A07599-1-400ul-safety-datasheet.pdf