Anti-DNAJB12 Antibody

Primary Antibodies

41860 MW

WB: 1:500-1:2000

DnaJ homolog subfamily B member 12

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Acts as a co-chaperone with HSPA8/Hsc70; required to
promote protein folding and trafficking, prevent aggregation of
client proteins, and promote unfolded proteins to endoplasmic
reticulum-associated degradation (ERAD) pathway (PubMed:21150129,
PubMed:21148293). Acts by determining HSPA8/Hsc70's ATPase and
polypeptide-binding activities. Can also act independently of
HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that
promotes maturation of potassium channels KCND2 and KCNH2 by
stabilizing nascent channel subunits and assembling them into
tetramers (PubMed:27916661). While stabilization of nascent
channel proteins is dependent on HSPA8/Hsc70, the process of
oligomerization of channel subunits is independent of HSPA8/Hsc70
(PubMed:27916661). When overexpressed, forms membranous structures
together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role
of these structures, named DJANGOs, is still unclear
(PubMed:24732912).

Boster Bio Anti-DNAJB12 Antibody catalog # A13448. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.