Anti-YTHDF3 Antibody

Primary Antibodies

63861 MW

WB: 1:500-1:2000
IHC: 1:50-1:100
ICC/IF: 1:50-1:100
IP: 1:50-1:200

YTH domain-containing family protein 3

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Specifically recognizes and binds N6-methyladenosine
(m6A)-containing RNAs and promotes RNA translation efficiency
(PubMed:28106072, PubMed:28106076, PubMed:28281539). M6A is a
modification present at internal sites of mRNAs and some non-
coding RNAs and plays a role in the efficiency of mRNA splicing,
processing and stability (PubMed:22575960, PubMed:24284625,
PubMed:28106072, PubMed:28106076, PubMed:28281539). Shares m6A-
containing mRNAs targets with YTHDF1 and YTHDF2, and regulates
different processes depending on the context (PubMed:28106072,
PubMed:28106076). Facilitates the translation of targeted mRNAs in
cooperation with YTHDF1 by binding to m6A-containing mRNAs and
interacting with 40S and 60S ribosome subunits (PubMed:28106072,
PubMed:28106076). Can also act as a regulator of mRNA stability in
cooperation with YTHDF2 by binding to m6A-containing mRNA and
promoting their degradation (PubMed:28106072). Recognizes and
binds m6A-containing circular RNAs (circRNAs) and promotes their
translation (PubMed:28281539). circRNAs are generated through
back-splicing of pre-mRNAs, a non-canonical splicing process
promoted by dsRNA structures across circularizing exons
(PubMed:28281539).

Boster Bio Anti-YTHDF3 Antibody catalog # A14443. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.