Anti-Macrosialin CD68 Monoclonal Antibody

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Monoclonal

CD68

CD68, cluster of differentiation, is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. CD68 is a member of a family of hematopoietic mucin-like molecules that includes leukosialin/CD43 and stem cell antigen CD34. The CD68 gene is mapped to 17p13.1. Immunohistochemistry can be used to identify the presence of CD68, which is found in the cytoplasmic granules of a range of different blood cells. It is particularly useful as a marker for the various cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance, such as the monocyte/macrophage and lymphoid forms of leukaemia (the latter being CD68 negative). Its presence in macrophages also makes it useful in diagnosing conditions related to proliferation or abnormality of these cells, such as malignant histiocytosis, histiocytic lymphoma, and Gaucher's disease.

PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide and 50% Glycerol.

1 mg/ml

Could play a role in phagocytic activities of tissue
macrophages, both in intracellular lysosomal metabolism and
extracellular cell-cell and cell-pathogen interactions. Binds to
tissue- and organ-specific lectins or selectins, allowing homing
of macrophage subsets to particular sites. Rapid recirculation of
CD68 from endosomes and lysosomes to the plasma membrane may allow
macrophages to crawl over selectin-bearing substrates or other
cells.

Boster Bio Anti-Macrosialin CD68 Monoclonal Antibody catalog # M00602-2. Tested in IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Boster Bio Anti-Macrosialin CD68 Monoclonal Antibody catalog # M00602-2. Tested in IF, IHC-P applications. This antibody reacts with Human, Mouse, Rat.