Anti-Hu CD314 Purified Azide Free KLRK1 Monoclonal Antibody

Store at 2-8°C. Do not freeze.

Monoclonal

KLRK1

CD314, also known as NKG2D (natural killer receptor G2D) or KLRK1 (killer cell lectin-like receptor subfamily K, member 1), is a homodimeric C-type lectin-like activating receptor and costimulator with type II membrane orientation (C teminus extracellular). CD314 homodimers are associated with DAP10, a membrane adaptor protein that signals similar to CD28 by recruitment of phosphatidylinositol 3-kinase. Engagement of CD314 amplifies antigen-specific T cell responses in CD314-positive T cell populations. In NK cells, CD314 is a primary activating receptor. As CD314 ligands the MHC class-I chain-related proteins A and B (MICA, MICB) and UL16-binding proteins (ULBPs) have been identified.

Phosphate buffered saline (PBS), pH 7.4, azide-free

1 mg/ml

Function as an activating and costimulatory receptor
involved in immunosurveillance upon binding to various cellular
stress-inducible ligands displayed at the surface of autologous
tumor cells and virus-infected cells. Provides both stimulatory
and costimulatory innate immune responses on activated killer (NK)
cells, leading to cytotoxic activity. Acts as a costimulatory
receptor for T-cell receptor (TCR) in CD8 (+) T-cell-mediated
adaptive immune responses by amplifying T-cell activation.
Stimulates perforin-mediated elimination of ligand-expressing
tumor cells. Signaling involves calcium influx, culminating in the
expression of TNF-alpha. Participates in NK cell-mediated bone
marrow graft rejection. May play a regulatory role in
differentiation and survival of NK cells. Binds to ligands
belonging to various subfamilies of MHC class I-related
glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6,
ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.

Boster Bio Anti-Hu CD314 Purified Azide Free KLRK1 Monoclonal Antibody (Catalog# M00661). Tested in Flow Cytometry, IP, IHC-F, Functional Assay application(s). This antibody reacts with Human.