Anti-T-bet/Tbx21 Antibody Picoband®

Primary Antibodies

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

58328 MW

Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

T-box transcription factor TBX21

TBX21 (T-Box 21), also called TBET, is a protein that in humans is encoded by the TBX21 gene. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Zhang and Yang (2000) mapped the mouse Tbx21 gene to chromosome 11D in an area showing homology of synteny with human chromosome 17. Szabo et al. (2000) showed that TBX21 expression correlates with IFNG expression in Th1 and natural killer (NK) cells. Ectopic expression of TBX21 both transactivated the IFNG gene and induced endogenous IFNG production. Finotto et al. (2002) observed reduced expression of the T (H)1 transcription factor Tbet in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of Tbet might be associated with asthma.

Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.

Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.

Adaptive Immunity, B Cells, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Hematopoietic Progenitors, Immunology, Non-CD, Stem Cells, Surface Molecules, T Cells, Transcription

Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.

Boster Bio Anti-T-bet/Tbx21 Antibody catalog # PA1999. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.