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Anti-Glucose Transporter GLUT1/SLC2A1 Antibody Picoband®

Anti-Glucose Transporter GLUT1/SLC2A1 Antibody Picoband®

Item no.	BOS-PB9435-PE
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Targets for Rodent Neurosciences Antibodies Flow Cytometry Immunohistochemistry Western Blot Immunofluorescence Immunocytochemistry Primary Antibodies By Organ Thyroid Cancer Immunochemistry
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, FC, IF, IHC, ICC, IHC-F
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	PE
Sensitivity	>5000 cells
Sequence	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Citations	1. Agus, D. B.; Gambhir, S. S.; Pardridge, W. M.; Spielholz, C.; Baselga, J.; Vera, J. C.; Golde, D. W. : Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J. Clin. Invest. 100: 2842-2848, 1997. 2. Heilig, C. W.; Saunders, T.; Brosius, F. C., III; Moley, K.; Heilig, K.; Baggs, R.; Guo, L.; Conner, D. : Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy. Proc. Nat. Acad. Sci. 100: 15613-15618, 2003. 3. Lazar, V.; Bidart, J.-M.; Caillou, B.; Mahe, C.; Lacroix, L.; Filetti, S.; Schlumberger, M. : Expression of the Na(+)/I(-) symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J. Clin. Endocr. Metab. 84: 3228-3234, 1999. 4. Manel, N.; Kim, F. J.; Kinet, S.; Taylor, N.; Sitbon, M.; Battini, J.-L. : The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell 115: 449-459, 2003.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Solute carrier family 2,facilitated glucose transporter member 1,Glucose transporter type 1,erythrocyte/brain,GLUT-1,HepG2 glucose transporter,SLC2A1,GLUT1
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	55 kDa
Calculated Molecular weight	54084 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat Immunohistochemistry (Frozen Section), 0.5-1μg/ml, Human, - Immunocytochemistry/Immunofluorescence , 2μg/ml, Human, - Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
Gene Name	SLC2A1
Gene Full Name	Solute carrier family 2, facilitated glucose transporter member 1
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	GLUT1, also known as SLC2A1, is a major glucose transporter in the mammalian blood-brain barrier whose gene is mapped to 1p35-p31.3 and contains 10 exons. It is present at high levels in primate erythrocytes and brain endothelial cells. Not only can transport dehydroascorbic acid (the oxidized form of vitamin C) into the brain, GLUT1 is also likely to contribute to HTLV-associated disorders through interacting with HTLV envelope glycoproteins. Functionally, GLUT1 deficiency causes a decrease in embryonic glucose uptake and apoptosis, which may be involved in diabetic embryopathy, by contrast, an increased expression of GLUT1 in some malignant tumors may suggest a role for glucose-derivative tracers to detect in vivo thyroid cancer metastases by positron-emission tomography scanning.
Immunogen	E.coli-derived human SLC2A1 recombinant protein (Position: R92-V492). Human SLC2A1 shares 98% and 98.3% amino acid (aa) sequence identity with mouse and rat SLC2A1, respectively.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Channels, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction
Protein Name	Solute carrier family 2, facilitated glucose transporter member 1
Protein Function	Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
Subcellular Localization	Cell membrane; Multi-pass membrane protein. Melanosome. Localizes primarily at the cell surface. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Description	Boster Bio Anti-Glucose Transporter GLUT1/SLC2A1 Antibody Picoband® catalog # PB9435. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues.
Sequence Similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PB9435-PE-datasheet.pdf

BOS-PB9435-PE-safety-datasheet.pdf