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Human recombinant NRG1 protein, AF

Human recombinant NRG1 protein, AF

Item no.	BOS-PROTQ02297-4-20ug
Manufacturer	Boster
Amount	20 ug
Quantity options	100 ug 20 ug 5 ug
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Signaling By Cell Type Carcinoma Melanoma Adenocarcinoma Neuronal Cell Markers Cell Culture
Format	Lyophilized
Applications	Cell Culture
Specific against	Human (Homo sapiens)
Conjugate/Tag	Tag Free
Sequence	A DNA sequence encoding Human NRG1 Protein (#Q02297)(Ser20-Lys241) was expressed.
Alias	Acetylcholine receptor-inducing activity (ARIA),Breast cancer cell differentiation factor p45,Glial growth factor,Heregulin (HRG),Neu differentiation factor,Sensory and motor neuron-derived factor
Available
Manufacturer - Category	Recombinant Proteins
Storage Conditions	Lyophilized protein should be stored at -20°C for 1 year. Upon reconstitution, store at 2°C to 8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20°C or -80°C for 3-6 months. Avoid repeated freeze/thaw cycles.
Molecular Weight	The protein has a calculated MW of 24.29 kDa. The protein migrates as 28-30 kDa under reducing condition (SDS-PAGE analysis).
Manufacturer - Format	The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 7.4. If you have any concerns or special requirements, please confirm with us.
Calculated Molecular weight	The protein has a calculated MW of 24.29 kDa.The protein migrates as 28-30 kDa under reducing condition (SDS-PAGE analysis).
Gene Name	NRG1
Purification	>95% as determined by SDS-PAGE.
Reconstitution	Centrifuge at 3000 rpm for 5 mins before opening. It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 100 μg/mL and incubate the stock solution at room temperature for at least 20 mins to ensure sufficient re-dissolved. Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.
Description	Neuregulin-1 (NRG-1, also called heuregulin1 or neu differentiation factor) is a glycoprotein that belongs to the neuregulins family. Structurally, Neuregulin-1 harbors tissue-speci?c N terminal sequence, followed by immunoglobulin-like (Ig-like) domains, an EGF-like domain, a transmembrane domain, and a cytoplasmic domain. Neuregulin-1 exerts its actions upon engagement of its EGF-like domain to the extracellular binding region of HER RTK family members (EGFR, HER2, HER3, and HER4), subsequently leading to receptor dimerization which activates a variety of signal pathways such as MAPK-ERK and PI3K-AKT pathways. These signal cascades are essential for regulating cardiac development, neuronal differentiation, neuromuscular synapses formation, and stem cell proliferation.
Bioactivity/Biological Activity	Testing in process
Endotoxin level	<1 EU per 1 μg of the protein by the LAL method.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PROTQ02297-4-20ug-datasheet.pdf

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Amount: 20 ug

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Delivery expected until 12/4/2025

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