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Anti-Caspase-6(P18)/CASP6 Antibody Picoband®

Anti-Caspase-6(P18)/CASP6 Antibody Picoband®

Item no.	BOS-PA1441
Manufacturer	Boster
Amount	100 ug/vial
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Colorectal Cancer Testicular & Prostate Cancer Gastric Cancer Uterine, Ovarian & Cervical Cancer
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, FC, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Sensitivity	<50pg/ml
Citations	1. Fernandes-Alnemri, T., Litwack, G., Alnemri, E. S.Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.Cancer Res. 55: 2737-2742, 1995. 2. Nikolaev, A., McLaughlin, T., O'Leary, D. D. M., Tessier-Lavigne, M.APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457: 981-989, 2009. 3. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., Dixit, V. M.The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.J. Biol. Chem. 271: 16443-16446, 1996.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Caspase-6;CASP-6;3.4.22.59;Apoptotic protease Mch-2;Caspase-6 subunit p18;Caspase-6 subunit p11;CASP6;MCH2;
Similar products	Caspase 6, Apoptosis Related Cysteine Protease antibody, Apoptotic cysteine protease MCH2 antibody, Apoptotic protease MCH 2 antibody, Apoptotic protease Mch-2 antibody, Apoptotic protease MCH2 antibody, Casp 6 antibody, CASP-6 antibody, Casp6 antibody, Caspase 6 antibody, Caspase 6 apoptosis related cysteine protease antibody, Caspase 6 precursor antibody, apoptosis related cysteine peptidase antibody, Caspase-6 subunit p18 antibody, Caspase6 antibody, Human cysteine protease Mch2 isoform alpha antibody, Mch 2 antibody, Mch2 antibody, OTTHUMP00000162742 antibody, OTTHUMP00000162743 antibody
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	35 kDa
Calculated Molecular weight	33310 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml, Human Immunohistochemistry (Paraffin-embedded Section), 2-5?g/ml, Human, By Heat Flow Cytometry (Fixed), 1-3 ?g/1x10⁶ cells, Human
Manufacturer - Gene Name	CASP6
Gene Full Name	Caspase-6
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Caspase 6 is an enzyme that in humans is encoded by the caspase 6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Using radiation hybrid mapping, the Caspase 6 gene is localized to human chromosome 4q25-q26. Caspase 6 functions as a downstream enzyme in the caspase activation cascade. And Caspase 6 can cleave lamin A to its signature apoptotic fragment.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-6(P18).
Contents	Each vial contains 4 mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Alzheimer's Disease, Apoptosis, Apoptotic Markers, Cancer, Caspases, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways and Processes
Protein Name	Caspase-6(CASP-6)
Protein Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly (ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Subcellular Localization	Cytoplasm.
Description	Boster Bio Anti-Caspase-6 (P18)/CASP6 Antibody catalog # PA1441. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human.
Tissue Specificity	High level expression seen in spleen and lung, low level expression seen in brain, heart, liver, kidney, testis and skeletal muscle.
Sequence Similarities	Belongs to the peptidase C14A family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-PA1441-datasheet.pdf

BOS-PA1441-safety-datasheet.pdf