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Anti-Leptin Receptor/LEPR Antibody

Anti-Leptin Receptor/LEPR Antibody

Manufacturer	Boster
Category	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Aging & Neurological Disorders Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Obesity Endocrine Regulation of Lipid Metabolism Primary Antibodies
Type	Antibody Polyclonal
Specific against	Human
Isotype	IgG
Format	Lyophilized
Applications	WB
Amount	100 ug/vial
Host	Rabbit
Item no.	BOS-PB9056
Targets	CDH11, CD295, LEP, FXN
eClass 6.1	32160702
eClass 9.0	32160702
Available
Background	Leptin receptor (or Obese receptor, OBR) is a single membrane-spanning receptor most related to the gp130 signal-transducing component of the IL-6 receptor, the G-CSF receptor, and the LIF receptor. OB-R mRNA is expressed not only in choroid plexus, but also in several other tissues, including hypothalamus. Leptin acts through the leptin receptor, a single-transmembrane domain receptor of the cytokine-receptor family. Leptin controls energy balance and food intake through the leptin receptor in the hypothalamus of the brain, which suggests that some polymorphisms of the leptin receptor gene (LEPR) might contribute to obesity or obesity-related diseases. Leptin is also involved in the regulation of blood pressure through the leptin receptor.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Description short	Rabbit IgG polyclonal antibody for Leptin receptor(LEPR) detection. Tested with WB in Human.
Gene Full Name	leptin receptor
Gene Name	LEPR
Immunogen	E.coli-derived human Leptin Receptor recombinant protein (Position: R465-D839). Human Leptin Receptor shares 81% and 82% amino acid (aa) sequence identity with mouse and rat Leptin Receptor, respectively.
Protein Name	Leptin receptor
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage	At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
Western blot	Concentration: 0.1-0.5ug/ml; Tested Species: Human

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