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Anti-NRG1 Antibody Picoband®

Anti-NRG1 Antibody Picoband®

Item no.	BOS-PB9299
Manufacturer	Boster
Amount	100 ug/vial
Category	Oncology Food Safety Allergenes Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Western Blot Primary Antibodies By Organ Lung Cancer Bladder Cancer Colorectal Cancer Breast Cancer Neuronal Cell Markers
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Sensitivity	<5pg/ml
Citations	1. Fazzari, P., Paternain, A. V., Valiente, M., Pla, R., Lujan, R., Lloyd, K., Lerma, J., Marin, O., Rico, B.Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature 464: 1376-1380, 2010. 2. Go, R. C. P., Perry, R. T., Wiener, H., Bassett, S. S., Blacker, D., Devlin, B., Sweet, R. A. Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses. Am. J. Med. Genet. 139B: 28-32, 2005.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Pro-neuregulin-1, membrane-bound isoform;Pro-NRG1;Neuregulin-1;Acetylcholine receptor-inducing activity;ARIA;Breast cancer cell differentiation factor p45;Glial growth factor;Heregulin;HRG;Neu differentiation factor;Sensory and motor neuron-derived factor;NRG1;GGF, HGL, HRGA, NDF, SMDF;
Similar products	alpha (45kD, Acetylcholine receptor inducing activity antibody\|Acetylcholine receptor-inducing activity antibody\|Acetylcholine receptor-inducing activity, CHICK, homolog of antibody\|ARIA antibody\|Breast cancer cell differentiation factor p45 antibody\|ERBB2 p185 activator antibody\|GGF 2 antibody\|GGF antibody\|GGF2 antibody\|Glial growth factor antibody\|Heregulin alpha antibody\|Heregulin antibody\|heregulin, membrane-bound isoform antibody\|Pro-NRG1 antibody\|Proneuregulin 1 antibody\|ProNRG1 antibody\|Sensory and motor neuron derived factor antibody\|Sensory and motor neuron-derived factor antibody\|SMDF antibody, ERBB2 p185-activator) antibody\|HGL antibody\|HRG 1 antibody\|HRG antibody\|HRG1 antibody\|HRGA antibody\|MST131 antibody\|NDF antibody\|Neu differentiation factor antibody\|Neuregulin 1 antibody\|neuregulin 1 type IV beta 1a antibody\|neuregulin 1 type IV beta 3 an
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	70 kDa
Calculated Molecular weight	70392 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml, Human
Manufacturer - Gene Name	NRG1
Gene Full Name	Pro-neuregulin-1, membrane-bound isoform
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).
Immunogen	E.coli-derived human NRG1 recombinant protein (Position: S2-K241). Human NRG1 shares 94% amino acid (aa) sequence identity with rat NRG1.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Growth and Development, Neurogenesis, Neurology Process, Neuroscience
Protein Name	Pro-neuregulin-1, membrane-bound isoform
Protein Function	ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
Subcellular Localization	Pro-neuregulin-1, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Does not seem to be active.
Description	Boster Bio Anti-NRG1 Antibody Picoband® catalog # PB9299. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.
Sequence Similarities	Belongs to the neuregulin family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PB9299-datasheet.pdf

BOS-PB9299-safety-datasheet.pdf