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Anti-Bcl-XS/BCL2L1 Antibody Picoband®

Anti-Bcl-XS/BCL2L1 Antibody Picoband®

Item no.	BOS-PA1232
Manufacturer	Boster
Amount	100 ug/vial
Category	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot Autophagy Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Colorectal Cancer Testicular & Prostate Cancer Lymphatic System Cancer
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	>5000 cells
Citations	1. "Entrez Gene: BCL2L1 BCL2-like 1". 2. Boise LH, González-García M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nuñez G, Thompson CB (Aug 1993). "bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death". Cell 74(4): 597–608.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Bcl-2-like protein 1;Bcl2-L-1;Apoptosis regulator Bcl-X;BCL2L1;BCL2L, BCLX;
Similar products	Apoptosis regulator Bcl X antibody, Apoptosis regulator Bcl-X antibody, Apoptosis regulator BclX antibody, B cell lymphoma 2 like antibody, B2CL1_HUMAN antibody, Bcl 2 like 1 protein antibody, Bcl X antibody, Bcl xL antibody, BCL XL/S antibody, Bcl xS antibody, Bcl-2-like protein 1 antibody, Bcl2 Like 1 antibody, Bcl2 related gene antibody, Bcl2-L-1 antibody, Bcl2l1 antibody, BCLX antibody, BclXL antibody, BclXs antibody, DKFZp781P2092 antibody, PPP1R52 antibody, Protein phosphatase 1 regulatory subunit 52 antibody
Available
Specificity	No cross reactivity with other proteins.
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	19 kDa
Calculated Molecular weight	26049 MW
Clonality	Polyclonal
Application Details	Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Human, By Heat Western blot, 0.1-0.5?g/ml, Human, Rat, Mouse
Manufacturer - Gene Name	BCL2L1
Gene Full Name	Bcl-2-like protein 1
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Bcl-xS is the second mRNA species of Bcl-x protein, which encodes a protein that inhibits the ability of bcl-2 to enhance the survival of growth factor-deprived cells. In vivo, bcl-xS mRNA is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. Apoptosis was associated with increased protein expression of Bcl-X/S, an early marker of apoptosis, and release of cytochrome c into the cytosol of infected HB cells.
Immunogen	A synthetic peptide corresponding to a sequence in the middle region of human Bcl-XS, different from the related rat and mouse sequences by one amino acid.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Apoptosis, Apoptotic Markers, Cancer, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes
Protein Name	Bcl-2-like protein 1(Bcl2-L-1)
Protein Function	Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Subcellular Localization	Isoform Bcl-X (L): Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49.
Description	Boster Bio Anti-Bcl-XS/BCL2L1 Antibody catalog # PA1232. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Bcl-X (S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X (L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Sequence Similarities	Belongs to the Bcl-2 family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PA1232-datasheet.pdf

BOS-PA1232-safety-datasheet.pdf