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Anti-SCN1B Antibody

Anti-SCN1B Antibody

Item no.	BOS-PA1244
Manufacturer	Boster
Amount	100 ug/vial
Category	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies Western Blot Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Brain Cancer
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GEFSP1 antibody, SCN1B antibody, SCN1B_HUMAN antibody, sodium channel beta 1 subunit antibody, Sodium channel subunit beta 1 antibody, Sodium channel subunit beta-1 antibody, Sodium channel voltage gated type I beta antibody, Sodium channel voltage gated type I beta subunit antibody
Similar products	GEFSP1 antibody, SCN1B antibody, SCN1B_HUMAN antibody, sodium channel beta 1 subunit antibody, Sodium channel subunit beta 1 antibody, Sodium channel subunit beta-1 antibody, Sodium channel voltage gated type I beta antibody, Sodium channel voltage gated type I beta subunit antibody
Available
Storage Conditions	At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.
Molecular Weight	24707 MW
Manufacturer - Gene Name	SCN1B
Gene Full Name	Sodium channel subunit beta-1
Background	Voltage-gated sodium(Na+) channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. The complete coding region of Sodium channel, voltage-gated, beta 1(SCN1B) is found in approximately 9.0 kb of genomic DNA and consists of five exons(72 to 749 bp) and four introns(90 bp to 5.5 kb). It is mapped to 19q13.1 and can act as a candidate gene for hereditary disorders affecting membrane excitability. Sodium channel beta1 subunits play important roles in the regulation of sodium channel density and localization and are involved in axo-glial communication at nodes of Ranvier.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of human SCN1B(72-94aa YENEVLQLEEDERFEGRVVWNGS), identical to the related rat and mouse sequences.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Add 0.2 ml of distilled water will yield a concentration of 500ug/ml.
Manufacturer - Research Category	\|neuroscience\|neurotransmission\|receptors / channels\|sodium channels\| signal transduction\|metabolism\|plasma membrane\| metabolism\|types of disease\|cancer
Protein Name	Sodium channel subunit beta-1
Protein Function	Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
Tissue Specificity	The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level).
Sequence Similarities	Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
Predicted Reactivity	Hamster

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PA1244-datasheet.pdf

BOS-PA1244-safety-datasheet.pdf