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Anti-nNOS (neuronal)/NOS1 Antibody Picoband®

Anti-nNOS (neuronal)/NOS1 Antibody Picoband®

Item no.	BOS-PA1329
Manufacturer	Boster
Amount	100 ug/vial
Category	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot Primary Antibodies By Organ Lung Cancer
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	>5000 cells
Citations	1. "Entrez Gene: NOS1 Nitric oxide synthase 1 (neuronal)". 2. Shteyer, E., Edvardson, S., Wynia-Smith, S. L., Pierri, C. L., Zangen, T., Hashavya, S., Begin, M., Yaacov, B., Cinamon, Y., Koplewitz, B. Z., Vromen, A., Elpeleg, O., Smith, B. C. Truncating mutation in the nitric oxide synthase 1 gene is associated with infantile achalasia. Gastroenterology 148: 533-536, 2015. 3. Xu, W., Gorman, P., Sheer, D., Bates, G., Kishimoto, J., Lizhi, L., Emson, P. Regional localization of the gene coding for human brain nitric oxide synthase (NOS1) to 12q24.2-24.31 by fluorescent in situ hybridization. Cytogenet. Cell Genet. 64: 62-63, 1993.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Nitric oxide synthase, brain;1.14.13.39;Constitutive NOS;NC-NOS;N
Similar products	Nitric oxide synthase, neuronal, penile neuronal, included antibody, 2310005C01Rik antibody, bNOS antibody, Constitutive NOS antibody, EC 1.14.13.39 antibody, IHPS 1 antibody, IHPS1 antibody, N NOS antibody, N-NOS antibody, NC NOS antibody, NC-NOS antibody, neuronal Nitric Oxide Synthase antibody, Neuronal NOS antibody, Nitric oxide synthase 1(neuronal) antibody, Nitric oxide synthase 1 antibody, Nitric oxide synthase brain antibody, brain antibody, nNOS antibody, NO antibody, NOS 1 antibody, NOS antibody, NOS type I antibody, NOS-I antibody, NOS1 antibody, NOS1_HUMAN antibody, Peptidyl-cysteine S-nitrosylase NOS1 antibody
Available
Specificity	No cross reactivity with other proteins.
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	160 kDa
Calculated Molecular weight	160970 MW
Clonality	Polyclonal
Application Details	Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Rat, Human, Mouse, By Heat Western blot, 0.1-0.5?g/ml, Human, Rat, Mouse
Manufacturer - Gene Name	NOS1
Gene Full Name	Nitric oxide synthase, brain
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Nitric oxide synthase 1 (neuronal), also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene. The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human nNOS(neuronal), identical to the related mouse and rat sequences.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Cadherins, Cell Adhesion, Cytoskeleton/ECM, Signal Transduction
Protein Name	Nitric oxide synthase, brain
Protein Function	Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
Subcellular Localization	Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine. In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).
Description	Boster Bio Anti-nNOS (neuronal)/NOS1 Antibody catalog # PA1329. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
Sequence Similarities	Belongs to the NOS family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PA1329-datasheet.pdf

BOS-PA1329-safety-datasheet.pdf