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Anti-5HT1A Receptor/HTR1A Antibody Picoband®

Anti-5HT1A Receptor/HTR1A Antibody Picoband®

Item no.	BOS-PA1647
Manufacturer	Boster
Amount	100 ug/vial
Category	Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Antibodies Obesity Immunohistochemistry Western Blot Cardiovascular Research Heart Failure Myocardial Infarction Hypertension Primary Antibodies Arrhythmias Other Lipid\Cholesterol Metabolism Modulators
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IHC
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	>5000 cells
Citations	1. Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ (November 1989). "Deletion Mapping of DNA Markers to a Region of Chromosome 5 That Cosegregates with Schizophrenia". Genomics 5 (4): 940–4. 2. Audero, E., Coppi, E., Mlinar, B., Rossetti, T., Caprioli, A., Banchaabouchi, M. A., Corradetti, R., Gross, C. Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. 3. El Mestikawy, S., Fargin, A., Raymond, J. R., Gozlan, H., Hnatowich, M. The 5-HT(1A) receptor: an overview of recent advances. Neurochem. Res. 16: 1-10, 1991.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	5-hydroxytryptamine receptor 1A;5-HT-1A;5-HT1A;G-21;Serotonin receptor 1A;HTR1A;ADRB2RL1, ADRBRL1;
Similar products	G protein coupled receptor antibody, 5 HT 1A antibody, 5 HT receptor 1A antibody, 5 HT1A antibody, 5 HT1A receptor antibody, 5 hydroxytryptamine(serotonin) receptor 1A antibody, 5 hydroxytryptamine(serotonin) receptor 1A G protein coupled antibody, 5 hydroxytryptamine receptor 1A antibody, 5-HT-1A antibody, 5-HT1A antibody, 5-hydroxytryptamine receptor 1A antibody, 5HT 1A antibody, 5HT 1A receptor antibody, 5HT receptor 1A antibody, 5HT1a antibody, 5HT1A_HUMAN antibody, ADRB2RL1 antibody, ADRBRL1 antibody, G 21 antibody, G-21 antibody, Gpcr 18 antibody, Gpcr18 antibody, Guanine nucleotide binding regulatory protein-coupled receptor antibody, HTR1A antibody, PFMCD antibody, Serotonin 1A receptor antibody, Serotonin 5HT1A receptor antibody, Serotonin receptor 1A antibody
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	46 kDa
Calculated Molecular weight	46107 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml, Human, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5?g/ml, Human, Rat, By Heat
Manufacturer - Gene Name	HTR1A
Gene Full Name	5-hydroxytryptamine receptor 1A
Background	HTR1A (5-HYDROXYTRYPTAMINE RECEPTOR 1A), also called SEROTONIN 5-HT-1A RECEPTOR or BETA-2-ADRENERGIC RECEPTOR-LIKE PROTEIN G-21, is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor.The HTR1A gene is located at 5q12.3. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5-HT-1A receptors has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. 5-HT-1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1 (NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor, different from the related rat and mouse sequences by one amino acid.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Cell Biology, Cell Cycle, Cell Division, Spindle
Protein Name	5-hydroxytryptamine receptor 1A(5-HT-1A/5-HT1A)
Protein Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca (2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Subcellular Localization	Cell membrane; Multi-pass membrane protein.
Description	Boster Bio Anti-5HT1A Receptor/HTR1A Antibody catalog # PA1647. Tested in IHC, WB applications. This antibody reacts with Human, Rat.
Tissue Specificity	Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.
Sequence Similarities	Belongs to the WD repeat BUB3 family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PA1647-datasheet.pdf

BOS-PA1647-safety-datasheet.pdf