Comparison

Anti-HCN1 Antibody Picoband® European Partner

Item no. BOS-PB9210
Manufacturer Boster
Amount 100 ug/vial
Category
Type Antibody Polyclonal
Format Lyophilized
Applications WB
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Sensitivity <5pg/ml
Citations 1. Santoro B, Grant SG, Bartsch D, Kandel ER (Feb 1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc Natl Acad Sci U S A 94 (26): 14815–20.
2. Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (Jul 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell 93 (5): 717–29.
3. Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev 57 (4): 455–62.
4. "Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1"
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1;Brain cyclic nucleotide-gated channel 1;BCNG-1;HCN1;BCNG1;
Similar products Potassium channel, brain, voltage-gated, 1 antibody, BCNG-1 antibody, BCNG1 antibody, Brain cyclic nucleotide gated channel 1 antibody, Brain cyclic nucleotide-gated channel 1 antibody, HAC 2 antibody, HAC2 antibody, HCN1 antibody, HCN1_HUMAN antibody, Hyperpolarization activated cyclic nucleotide gated potassium channel 1 antibody, Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1 antibody, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 antibody
Available
Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Rabbit IgG
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
120 kDa
Calculated Molecular weight
98796 MW
Clonality
Polyclonal
Application Details
Western blot, 0.1-0.5?g/ml, Human, Mouse, Rat
Manufacturer - Gene Name
HCN1
Gene Full Name
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, also known as HAC-2 or BCNG-1, is a protein that in humans is encoded by the HCN1 gene. It is mapped to 5p12. The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. It may mediates responses to sour stimuli.
Immunogen
E.coli-derived human HCN1 recombinant protein (Position: E618-L890). Human HCN1 shares 82% amino acid (aa) sequence identity with both mouse and rat HCN1.
Contents
Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category
Cardiovascular, Contractility, Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels
Protein Name
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Protein Function
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
Subcellular Localization
Cell membrane; Multi-pass membrane protein.
Description
Boster Bio Anti-HCN1 Antibody Picoband® catalog # PB9210. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity
Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.
Sequence Similarities
Belongs to the potassium channel HCN family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug/vial
Available: In stock
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