Anti-NOD2 (Card15) Antibody

Rabbit IgG

115283 MW

WB: 1:1000-1:2000
IHC (paraffin): 1:1000-1:5000
IHC (frozen): Users should optimize
IP: 1:50-1:200

Nucleotide-binding oligomerization domain-containing protein 2

50 μ l sera

Apoptosis, Caspases, Cell Biology, Intracellular

Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).

Boster Bio Anti-NOD2 (Card15) Antibody (Catalog# A00087). Tested in WB, IHC, IP application(s). This antibody reacts with Human.

Monocytes-specific.