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Anti-CDA Antibody Picoband®

Anti-CDA Antibody Picoband®

Item no.	BOS-A01578-1
Manufacturer	Boster
Amount	100 ug/vial
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody
Format	Lyophilized
Applications	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	1. Demontis, S., Terao, M., Brivio, M., Zanotta, S., Bruschi, M., Garattini, E. Isolation and characterization of the gene coding for human cytidine deaminase. Biochim. Biophys. Acta 1443: 323-333, 1998. 2. Fitzgerald, S. M., Goyal, R. K., Osborne, W. R. A., Roy, J. D., Wilson, J. W., Ferrell, R. E. Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter. Hum. Genet. 119: 276-283, 2006. 3. Jahns-Streubel, G., Reuter, C., Auf der Landwehr, U., Unterhalt, M., Schleyer, E., Wormann, B., Buchner, T., Hiddemann, W. Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colony-stimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia. Blood 90: 1968-1976, 1997.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Cytidine deaminase; Cytidine aminohydrolase; CDA; CDD
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	16 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml
Manufacturer - Gene Name	CDA
Gene Full Name	cytidine deaminase
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene. This gene is mapped to 1p36.12. It encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of human CDA, which shares 63% amino acid (aa) sequence identity with both mouse and rat CDA.
Contents	Each vial contains 4 mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05 mg NaN₃.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling
Protein Function	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Subcellular Localization	Cytosol, Extracellular region, Ficolin-1-rich granule lumen, Secretory granule lumen, Tertiary granule lumen.
Description	Boster Bio Anti-CDA Antibody Picoband® catalog # A01578-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-A01578-1-datasheet.pdf

BOS-A01578-1-safety-datasheet.pdf