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Anti-Gab1(Phospho-Tyr627) Antibody

Anti-Gab1(Phospho-Tyr627) Antibody

Item no.	BOS-A01989
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Neural Signaling Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Type	Antibody
Format	Liquid
Applications	WB, IF
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GRB2-associated-binding protein 1;GRB2-associated binder 1;Growth factor receptor bound protein 2-associated protein 1;GAB1;
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	76616 MW
Clonality	Polyclonal
Application Details	Predicted MW: 110kd Western blotting: 1:500~1:1000 Immunofluorescence: 1:100~1:200
Manufacturer - Gene Name	GAB1
Gene Full Name	GRB2-associated-binding protein 1
Background	The protein encoded by Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Anders Kallin, et al. (2004) J. Biol. Chem ; 279: 17897 - 17904. Hideto Kameda, et al. (2001) Cell Growth Differ ; 12: 307. Masaki Osawa, et al. (2002) J. Cell Biol ; 158: 773.
Immunogen	Peptide sequence around phosphorylation site of tyrosine 627 (V-E-Y(p)-L-D) derived from Human Gab1.
Contents	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration	1 mg/ml
Manufacturer - Research Category	Adapters, Apoptosis, Cancer, Cell Biology, Cell Cycle, Cell Differentiation, Cytoplasmic, Intracellular, Kinases, MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction
Protein Function	Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
Short Description	Boster Bio Anti-Gab1(Phospho-Tyr627) Antibody (Catalog # A01989). Tested in WB, IF applications. This antibody reacts with Human, Mouse.
Description	Boster Bio Anti-Gab1(Phospho-Tyr627) Antibody (Catalog # A01989). Tested in WB, IF applications. This antibody reacts with Human, Mouse.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A01989-datasheet.pdf

BOS-A01989-safety-datasheet.pdf