Anti-Cyclin-L1 CCNL1 Antibody

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Polyclonal

CCNL1

Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
A. Hamid Boulares, J. Biol. Chem., Aug 1999; 274: 22932.
Alessandra Pagano, Am J Physiol Lung Cell Mol Physiol, Jun 2007; 10.1152.
Mi Young Kim, Genes & Dev., Sep 2005; 19: 1951 - 1967.
Silke S¨¹sse, Nucleic Acids Res., Feb 2004; 32: 669 - 680.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1 mg/ml

Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).

Boster Bio Anti-Cyclin-L1 CCNL1 Antibody (Catalog # A04105). Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).