Anti-Myosin-11 MYH11 Antibody

Store at -20°C. For long-term storage, store at -80°C. Avoid multiple freeze-thaw cycles.

Polyclonal

MYH11

MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family which function as major contractile proteins. MYH11 is involved in a pericentric inversion of chromosome 16 (inv (16) (p13q22)) which produces a chimeric transcript consisting of the N terminus of CBFb and the C-terminal portion MYH11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype.References citing this antibody (1) Mandoli A, Singh AA, Jansen PWTC, Wierenga ATJ, Riahi H, Franci G, Prange K, Saeed S, Vellenga E, Vermeulen M, Stunnenberg HG and Martens JHA (2013) CBFB– MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv (16) acute myeloid leukemia. Leukemia: 1-9.

Whole antiserum from rabbit containing 0.05% azide.

0.5-1 mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Myosin-11

Boster Bio Anti-Myosin-11 MYH11 Antibody (Catalog# CI1028). Tested in ChIP, ChIP-seq, ELISA, WB applications. This antibody reacts with Human.

Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 is mostly found in slowly contracting tonic muscles.