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Anti-BMI1 Antibody ChIP Grade

Anti-BMI1 Antibody ChIP Grade

Item no.	BOS-CI1117
Manufacturer	Boster
Amount	100 ul
Category	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies By Cell Type Carcinoma Hematology Leukemia ELISA Primary Antibodies
Type	Antibody
Applications	ELISA
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Polycomb complex protein BMI-1,Polycomb group RING finger protein 4,RING finger protein 51,BMI1,PCGF4, RNF51,
Available
Storage Conditions	At -20°C for one year, at 4°C for one month. Avoid repeated freezing and thawing.
Observed Molecular Weight	36949 MW
Clonality	Polyclonal
Manufacturer - Gene Name	BMI1
Background	BMI1 is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of lysine 119 on histone H2A, rendering chromatin heritably changed in its expressibility. BMI1 is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 in the PRC1 complex.
Immunogen	This antibody is raised in rabbit against mouse BMI1 (BMI1 polycomb ring finger oncogene) using two KLH-conjugated synthetic peptides containing a sequence from the central and the C-terminal region of the protein, respectively.
Contents	Whole antiserum from rabbit containing 0.05% azide.
Purification	Whole antiserum
Manufacturer - Research Category	\|cell biology\|cell cycle\|cell differentiation\| epigenetics and nuclear signaling\|chromatin remodeling\|polycomb silencing\|prc2\|transcription\|cancer susceptibility\|proto-oncogenes\| stem cells\|hematopoietic progenitors\|intracellular molecules\| cancer\|oncoproteins/suppressors\|oncoproteins\|chip'ing antibodies
Protein Function	Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-CI1117-datasheet.pdf

BOS-CI1117-safety-datasheet.pdf