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Anti-PIWIL1/Hiwi Antibody ChIP Grade

Anti-PIWIL1/Hiwi Antibody ChIP Grade

Item no.	BOS-CI1120
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Neuroinflammation Neural Epigenetics Antibodies ELISA Primary Antibodies
Type	Antibody
Applications	ELISA
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Piwi-like protein 1,PIWIL1,HIWI,
Available
Storage Conditions	At -20°C for one year, at 4°C for one month. Avoid repeated freezing and thawing.
Observed Molecular Weight	98603 MW
Clonality	Polyclonal
Manufacturer - Gene Name	PIWIL1
Background	PIWIL1 plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. PIWIL1 acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. It directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. PIWIL1 probably is a component of some RISC complex, which mediates RNA cleavage and translational silencing. It also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability.
Immunogen	This antibody is raised in rabbit against human PIWIL1 (piwi-like 1) using two KLH-conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively.
Contents	Whole antiserum from rabbit containing 0.05% azide.
Purification	Whole antiserum
Manufacturer - Research Category	\|epigenetics and nuclear signaling\|dna / rna\|rna processing\|rnai\| epigenetics and nuclear signaling\|risc\|argonaute and piwi
Protein Function	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-CI1120-datasheet.pdf

BOS-CI1120-safety-datasheet.pdf