Anti-HER2 Rabbit Monoclonal Antibody, Clone#RM228

Rabbit IgG

137910 MW

Immunohistochemistry (IHC): 1:100 dilution

WB: 1:1000 dilution.

Receptor tyrosine-protein kinase erbB-2

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Boster Bio Anti-HER2 Rabbit Monoclonal Antibody, Clone#RM228 (Catalog # M00010-2). Tested in IHC, WB applications. This antibody reacts with Human.

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.