Anti-Apg12 (Atg12) Rabbit Monoclonal Antibody

Rabbit Monoclonal Antibodies

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

15113 MW

WB 1:1000-1:5000
IHC 1:50-1:200
ICC/IF 1:50-1:200

Ubiquitin-like protein ATG12

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5 mg/ml BSA.

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Cancer, Cell Biology, Nucleotide Metabolism

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.

Boster Bio Anti-Apg12 (Atg12) Rabbit Monoclonal Antibody catalog # M00820. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.