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Anti-PAX8 (Renal Cell Marker) Monoclonal Antibody

Anti-PAX8 (Renal Cell Marker) Monoclonal Antibody

Item no.	BOS-M00943
Manufacturer	Boster
Amount	100 ug
Category	Oncology Antibodies Immunohistochemistry Immunofluorescence Primary Antibodies By Organ Renal Cancer
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, FC, IF, IHC
Clone	PAX8/1492
Specific against	Human (Homo sapiens), Dog (Canine, Canis lupus familiaris)
Host	Mouse
Isotype	IgG2b Kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Paired box protein Pax-8;PAX8;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, 2279
Storage Conditions	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Observed Molecular Weight	48218 MW
Clonality	Monoclonal
Application Details	Flow Cytometry (1-2ug/million cells) Immunofluorescence (1-2ug/ml) Western Blot (1-2ug/ml) Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Manufacturer - Gene Name	PAX8
Gene Full Name	Paired box protein Pax-8
Background	Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.
Immunogen	Recombinant fragment (around aa 60-261) of human PAX8 protein (exact sequence is proprietary)
Contents	Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purification	200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
Concentration	Purified antibody with BSA and azide at 200ug/ml
Manufacturer - Research Category	Auditory System, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Neuroscience, Sensory System, Transcription
Protein Function	Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
Subcellular Localization	Nuclear
Short Description	Boster Bio Anti-PAX8 (Renal Cell Marker) Monoclonal Antibody (Catalog # M00943). Tested in Flow Cytometry, IF, WB, IHC applications. This antibody reacts with Human, Dog.
Description	Boster Bio Anti-PAX8 (Renal Cell Marker) Monoclonal Antibody (Catalog # M00943). Tested in Flow Cytometry, IF, WB, IHC applications. This antibody reacts with Human, Dog.
Tissue Specificity	Expressed in the excretory system, thyroid gland and Wilms tumors.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M00943-datasheet.pdf

BOS-M00943-safety-datasheet.pdf