Comparison

Anti-Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Monoclonal Antibody European Partner

Item no. BOS-M30943
Manufacturer Boster
Amount 100 ug
Category
Type Antibody Monoclonal
Format Liquid
Applications IHC
Clone KRT6/1702
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host Mouse
Isotype IgG2a Kappa
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Keratin, type II cytoskeletal 6A;Cytokeratin-6A;CK-6A;Cytokeratin-6D;CK-6D;Keratin-6A;K6A;Type-II keratin Kb6;Hom s 5;KRT6A;K6A, KRT6D;
Available
Manufacturer - Category
Primary Antibodies, Monoclonal Antibodies, 2279
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Observed Molecular Weight
60045 MW
Clonality
Monoclonal
Application Details
Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
Manufacturer - Gene Name
KRT6A; KRT6B; KRT6C
Gene Full Name
Keratin, type II cytoskeletal 6A
Background
This monoclonal antibody recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.
Immunogen
Recombinant human keratin 6 protein
Contents
Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purification
200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
Concentration
Purified antibody with BSA and azide at 200ug/ml
Manufacturer - Research Category
Class I, Cytoskeleton, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Intermediate Filaments, Microtubules, Signal Transduction, Structures
Protein Function
Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
Subcellular Localization
Cytoplasmic
Short Description
Boster Bio Anti-Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Monoclonal Antibody (Catalog # M30943). Tested in IHC applications. This antibody reacts with Human, Mouse.
Description
Boster Bio Anti-Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Monoclonal Antibody (Catalog # M30943). Tested in IHC applications. This antibody reacts with Human, Mouse.
Tissue Specificity
Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
available

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