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Human Cathepsin D ELISA Kit PicoKine®

Human Cathepsin D ELISA Kit PicoKine®

Manufacturer	Boster
Category	Oncology Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Cell Biology Cell Status Apoptosis ELISA ELISA & Immunoassays ELISA Kits Immunoassay By Organ Breast Cancer Testicular & Prostate Cancer
Type	Elisa-Kit
Specific against	Human
Applications	ELISA
Amount	96 wells/kit, with removable strips.
Item no.	BOS-EK0672
Targets	CTSD
eClass 6.1	32160605
eClass 9.0	32160605
Available
Manufacturers Product Category	PicoKine® ELISA Kits
Manufacturers Research Category	Cancer, Cell Adhesion Proteins, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Membrane Proteins, Neuroscience, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction
Short Description	Human Cathepsin D ELISA Kit PicoKine® (96 Tests). Quantitate Human CTSD in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10 pg/ml.
Description	Human Cathepsin D ELISA Kit PicoKine® (96 Tests). Quantitate Human CTSD in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10 pg/ml.
Background	Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of the peptidase C1 family, having a specificity similar to but narrower than that of pepsin A. It is mapped to 11p15.5. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in a pre- and prosegment, respectively. Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease and it has been considered as a breast cancer tumor marker.
Gene Name	CTSD
Application Details	Dilution ratio of 1:100, concentration in serum and plasma is 125-250 ng/ml.
Immunogen	Expression system for standard: NS0; Immunogen sequence: L21-L412
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).
Capture antibody\|Detection antibody	monoclonal antibody from mouse\|polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin or EDTA
Gene Full Name	Cathepsin D
Molecular Weight	44552 MW
Protein Function	Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Subcellular Localization	Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380)..
Tissue Specificity	Expressed in the aorta extrcellular space (at protein level)..
Protein Name	Cathepsin D
Sequence Similarities	Belongs to the peptidase A1 family.

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