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Mouse Hemojuvelin/RGM-C/HJV ELISA Kit PicoKine®

Mouse Hemojuvelin/RGM-C/HJV ELISA Kit PicoKine®

Manufacturer	Boster
Category	Oncology ELISA ELISA & Immunoassays ELISA Kits Immunoassay By Organ Testicular & Prostate Cancer
Type	Elisa-Kit
Specific against	Mouse
Applications	ELISA
Amount	96 wells/kit, with removable strips.
Item no.	BOS-EK1370
eClass 6.1	32160605
eClass 9.0	32160605
Available
Manufacturers Product Category	PicoKine® ELISA Kits
Short Description	Mouse Hemojuvelin/RGM-C/HJV ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Hjv in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.
Description	Mouse Hemojuvelin/RGM-C/HJV ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Hjv in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.
Background	Hemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals. It is a member of a three gene family (in vertebrates) called the repulsive guidance molecules. In mouse, the Hemojuvelin protein is encoded by the HFE2 gene, and it is mapped to Chromosome 3. It was concluded that downregulation of hepatic Hemojuvelin during inflammation may induce a temporary elimination of iron sensing. Hemojuvelin is a coreceptor for bone morphogenetic proteins (BMPs), and inhibition of endogenous BMP signaling reduces hepcidin expression and increases serum iron in mice. Furthermore, Hemojuvelin may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion.
Gene Name	HFE2
Application Details	Dilution ratio of 1:1, concentration in serum and plasma is 600-900 pg/ml.
Immunogen	Expression system for standard: NS0; Immunogen sequence: Q33-D393
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).
Capture antibody\|Detection antibody	monoclonal antibody from rat\|polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin or EDTA
Gene Full Name	Hemojuvelin
Molecular Weight	44848 MW
Protein Function	Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis..
Subcellular Localization	Cell membrane ; Lipid-anchor, GPI-anchor. Also released in the extracellular space..
Tissue Specificity	Muscle cell lineage..
Protein Name	Hemojuvelin

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